Ultrasound is known for its use in imaging during pregnancy. But new advancements in the technology suggest that in the future, ultrasound  could be used to disrupt the blood-brain barrier. This would allow doctors to more easily diagnose and directly treat illnesses like brain cancer without major surgery. WSJ’s Danny Lewis and Charlotte Gartenberg examine the new ways that ultrasound could be used more specifically and subtly to deliver accurate diagnoses and precise treatments.



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Further reading:



New Ultrasound Therapy Could Help Treat Alzheimer’s, Cancer 

Treatment Breakthrough for an Intractable Brain Cancer 

The ‘Mini Brains’ solving medical mysteries and raising concerns

We Can Now See the Brain Like Never Before 

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Ultrasound Isn’t Just for Pregnancy. How It’s Helping Treat the Brain.

What will the future look like? The Future of Everything offers a view of the nascent trends that will shape our world. In every episode, join our award-winning team on a new journey of discovery. We’ll take you beyond what’s already out there, and make you smarter about the scientific and technological breakthroughs on the horizon that could transform our lives for the better.

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How did a sandal that originally entered the U.S. market as a health product become a fashion staple and the crowning shoe of a multibillion dollar company? Margot Fraser originally brought Birkenstocks to the U.S. thinking that the comfort of the German sandal would appeal to women. But she couldn’t get shoe stores to sell them. They finally made it into the U.S. market through health food stores. Now, the seductively ugly shoe is a cultural icon and was valued at about $8.6 billion when the company went public last year. WSJ’s Ben Cohen explores the history of Birkenstock and how it paved the way for the future of women’s feet.



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Further reading: 

Why Americans Are Obsessed With These Ugly Sandals 

A Key to Birkenstock’s Billion Dollar Success? Its Frumpiest Shoe 

A Visual History of Birkenstock’s Rise, From Insoles to IPO 

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Science of Success: Birkenstocks and the Promise of Healthy Feet

How does your doctor know that a drug or procedure will work to treat a condition before they try it? Often, they don’t. Researchers are looking to create “digital twins,” digital versions of individual organs, to see how a patient will respond. Eventually there could be digital twins of entire bodies that are updated in real time with patient data. WSJ’s Alex Ossola speaks with WSJ senior special writer Stephanie Armour about how that might change the way we treat diseases in the future. 



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Further reading: A ‘Digital Twin’ of Your Heart Lets Doctors Test Treatments Before Surgery  

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Will a Treatment Work? Try the 'Digital Twin' First.

A day when people can interact directly with computers using their thoughts could be on the horizon. Several companies, including Elon Musk’s Neuralink, have begun preliminary human trials of brain-computer interfaces - devices that decode the electrical signals in their brain and translate them into digital bits. Neurosurgeon Benjamin Rapoport is a co-founder and chief science officer of Precision Neuroscience, a company working on brain-computer interfaces. He spoke with WSJ’s Danny Lewis about how the technology works and how these implants could improve the lives of hundreds of thousands of people who could gain the ability to independently engage with the digital world.



Correction: Dr. Benjamin Rapoport is the co-founder of Precision Neuroscience. An earlier version misspelled his name Rapaport. (Corrected on May 3)



What do you think about the show? Let us know on Apple Podcasts or Spotify, or email us: FOEPodcast@wsj.com 



Further reading: 

Inside the Operating Room: Doctors Test a Revolutionary Brain-Computer Implant 

Elon Musk’s Neuralink Wants to Make ‘The Matrix’ a Reality. It Has a Lot to Prove First. 

She Didn’t Speak for 18 Years. A Computer Helped Find Her Voice. 

The Devices That Will Read Your Brain—and Enhance It 



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Chip in the Brain? How Brain-Computer Interfaces Could Change Medicine

What does the brick and mortar bookstore of the future look like? For Barnes & Noble, it looks more like the indie bookstores they once threatened to put out of business 20 years ago. The company recently redesigned their national chain of over 500 bookstores, shedding the big box personality in favor of a look reminiscent of local bookshops. On this week’s Science of Success, WSJ columnist Ben Cohen speaks to Barnes & Noble CEO James Daunt about the look, feel and idea behind Barnes & Noble’s new indie design.



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Further reading:

That Cool New Bookstore? It’s a Barnes & Noble.

New CEO Wants to Make Barnes & Noble Your Local Bookstore

Barnes & Noble’s New Boss Tries to Save the Chain—and Traditional Bookselling 

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Ultrasound Isn’t Just for Pregnancy. How It’s Helping Treat the Brain.

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