On this episode, I discuss the new medication vonoprazan and where it will likely be used in practice.



Vonoprazan is from a brand new class of medication called "PCAB". I discuss this medication and its pharmacology in this podcast episode. 



Drug interactions and cost are the two major downsides of this medication that will likely limit its use compared to the PPIs. 



CYP3A4 inducers like rifampin, carbamazepine, and phenytoin should not be used with vonoprazan. They will reduce the effectiveness of vonoprazan.

Vonoprazan Pharmacology – New Esophagitis Medication Class! Episode 326

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Health & Fitness

On this episode, I discuss timolol pharmacology, adverse effects, drug interactions, and much more. 



Timolol is a non-selective beta-blocker so it blocks both beta-1 and beta-2 receptors. 



Since timolol blocks beta-2 receptors, it can blunt the effect of respiratory medications that have beta-agonist action. 



Beta-blockers are notorious for causing bradycardia and pulse is an important monitoring parameter for timolol.

Timolol Pharmacology Podcast

Continuous Glucose Monitors (CGMs) are becoming an important tool in the management of diabetes. I break down some of the most common clinical practice pearls you should know.

Continuous Glucose Monitors Podcast

On this episode of the Real Life Pharmacology Podcast, I cover some of the most common food and supplement drug interactions. 



The 3 G's can potentially increase the risk of bleeding in patients on anticoagulants and antiplatelets. I discuss what supplements these are. 



There are some vitamins that can cause drug interactions. Vitamin C is a supplement that can alter the absorption of some medications. 



Metal cations like iron can bind certain medications and reduce absorption. I discuss which medications are most likely to be affected.

Food and Supplement Drug Interactions

Today’s sponsor of the 10 Commandments of Polypharmacy podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.



FreedAI is offering a discount exclusive to RLP listeners! Users will get $50 off their first month with Freed! Use the discount code: RLPPOD



Here is part 2 of 2 on the final 5 of the 10 commandments of polypharmacy. 



6. Thou shalt identify limits for medications not intended for chronic use as well as not continue a medication indefinitely for symptoms that have an expected short duration



7. Thou shalt not start a medication from a similar medication class without appropriate rationale



8. Thou shalt not initiate a medication without considering medications that may treat duplicate conditions – Kill two birds with one stone



9. Thou shalt consider eliminating or reducing medications at every medication review



10. Thou shalt be willing to accept risk in discontinuing a medication if they were willing to accept the risk of initiating a medication

Vonoprazan Pharmacology – New Esophagitis Medication Class! Episode 326

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